Messologi, the "sacred city" at it is called, is identified with the Revolution of 1821. There are many evidences of its role in the Greek Liberation such as the gate of the exodus, the sandy fence, the garden of the heroes and the tomb of the warriors who were killed during the siege of the city, statues of the warriors and the philhellenes as well as of Markos Botsaris, Kiriakoulis Mavromichalis, N. Stournaras, Byron, Dimotselios, Vlahopoulos, Kapsalis, Razikotsikas, priest Rogon, Makris and of Spiromilios. There is a collection of paintings in town hall. This collection, apart from paintings by Greek and foreign painters of the 19th and 20th century, also includes lithographs and various relative to the fight items: papers from the Greek Records written by Mayers, items of Byron who died in Messologi and other things. Kostis Palamas was from Messologi and also Spiridon Trikoupis, Harilaos Trikoupis and Miltiadis Malakasis were born there.
Messologi's salt lagoon. It is the most important salt lake that is created between the mouths of the Evinos and the Aheloos River. Its depth is very small, just 0,45 - 1,65m. Many sea currents bring bulks of sand at the end of the gulf and as a result there have been created many long small islands which close the opening and create a salt lake. There is a canal for the ships. The salt lake's northern part becomes narrow and there is a small island on which Etolikos built. After this point it becomes again wide and it forms the salt lake of Etoliko. The almost quadrangular small salt lake of Kleisovas has been formed in the south - east of the Messologi's salt lagoon.

Agrinio: According to mythology, it was built by king Agrios, Thestia's son. It was destroyed by Kassandros in 314 BC. In 1585 it was deserted during the revolt of Theodoros Migas. At the beginning of the 16th century it became the administrative center of Aitoloakarnania, depended on the imperial harems. It participated in the Greek Revolution. It was temporarily liberated on 11 June, 1821. It became member of the newborn state permanently in 1832 with the treaty of Keleder Kiosi. It was again named Agrinio in 1925 - during the Turkish rule it was called Vrahori. It developed into an important productive and urban center in the district. It has good tourist facilities. You can use this town as your starting point for your excursions to other areas to the prefecture.

Antirio: A seaside village at the homonymous cape, 34klm from Mesologi, with 2.375 residents. A communicational knot which connects the whole area with Peloponnisos by ferry boat. There are remains of a castle built by sultan Vayiazit and mended by the Venetian.

Vonitsa: A coastal small city at the entrance of the Amvrakikos gulf. It is 114klm from Mesologi and it has 4.081 residents. It was founded in the 4th century AD. In the 14th century it subjugated to the king of Neapolis, in the 15th century it subjected to the Venetian, in 1797 to the French and then to Ali pasha. It liberated in 1828. In 1862 it was the capital of Griva's revolution against Othona. The city was built on the foundations of the ancient Anaktorio.

Nafpaktos: It is the third big city of this district. It retains intensively its picturesque style. Eparhos, the only touristically organized city of the district, was built in 1000 BC by Doris and it had an important role in history. It was an Athenian possession in the classical period and then many people from Messinia were settled there. After the Spartans' victory in 405 BC., Nafpaktos became independent and its Messinian residents were made to move into Sicily. There were many temples and sanctuaries in the city, as well as a cave dedicated to Aphrodite. It was known for the sculpture school of Menehmos and Soidas. After the Roman rule, the Byzantine and the Venetian made it a naval station.